Nanoparticle Analyzer
The HORIBA SZ-100V2 Nanoparticle Analyzer is an advanced, multi-parameter instrument designed to characterize nanoparticles with precision and ease. Combining particle size, zeta potential, and molecular weight measurements in a single compact system, it offers a powerful solution for nanotechnology research and quality control. With high sensitivity optics, minimal sample requirements, and broad concentration coverage, the SZ-100V2 delivers reliable results across diverse applications including life sciences, pharmaceuticals, polymers, food, cosmetics, and advanced materials.
- Three-in-One Analysis – Measures particle size (0.3 nm to 10 μm), zeta potential (–500 to +500 mV), and molecular weight (10³ to 10⁷ Da) in a single device.
- Wide Concentration Range – Dual optical system enables analysis of both high-concentration samples (slurries, inks) and low-concentration proteins or polymers without extensive preprocessing.
- Minimal Sample Volume – Microvolume cells allow measurements with as little as 100 μL, ideal for rare or valuable samples.
- High Sensitivity Optics – Utilizes green laser and photomultiplier tube (PMT) detection for superior accuracy and dynamic range.
- Advanced Zeta Potential Measurement – Carbon electrodes minimize corrosion, ensuring stability even with high-salt samples.
- Maintenance-Free Design – Disposable or easily cleaned cells simplify operation and reduce downtime.
- Regulatory Compliance – Supports 21 CFR Part 11 for data integrity in regulated industries.
- Versatile Applications – Suitable for research in nanomaterials, drug delivery systems, protein stability, colloids, and more.
Particle Size Measurement Principle
The SZ-100V2 uses the technique of dynamic light scattering to determine particle size. Dynamic light scattering is the measurement of fluctuations in scattered light intensity with time. These fluctuations in intensity arise due to the random Brownian motion of the nanoparticles. Therefore, the statistical behavior of these fluctuations in scattered intensity can be related to the diffusion of the particles. Since larger particles diffuse more slowly than small particles one can readilyrelate particle size to measured fluctuations in light scattering intensity. With modern instruments such as the SZ-100V2 the technique is rapid and reliable.
Features of HORIBA’s Optical System
1. High Sensitivity Optical Components
The key to accurately and rapidly evaluating size with dynamic light scattering is to use a high-energy laser light source and a sensitive detector. HORIBA uses a green laser. Scattering intensity is inversely proportional to the fourth power of wavelength. Therefore, the green laser gives more scattering intensity per milliwatt than the more commonly used red laser. Since avalanche photodiodes, APD’s, are less sensitive to green light and photomultiplier tubes PMT’s, are more sensitive to green light, HORIBA has included the most sensitive PMT detector available. In addition, the dead time of a PMT is shorter than that of an APD and therefore the PMT detector dynamic range is superior.
2. Conformance with Standards
The SZ-100V2 series conforms to ISO 13321:1996 and JIS Z8826:2005.
3. Automatic Measurement Optimization
The analyzer features the ability to measure particle size under a number of conditions. In order to eliminate guesswork, measurement conditions can be automatically selected for each sample by using data obtained from that sample.
The three-angle system of the SZ-100V2 enables analysis of a wide range of high concentration and dilute samples.
The optical configurations shown can be automatically selected depending on the concentration of the analyzed sample
